When Histamine Goes Haywire: Sixteen Other Essential Oils (From M- Z) for Supporting Balanced Histamine Levels, Taming Inflammation, and Enhancing a Healthy Immune Response

Help for Harmonizing Excess Histamine

In this video post series, we’ve been exploring how excess histamine in the body impacts our health (e.g., allergies, histamine intolerance, and MCAS) and how essential oils can help to aid in the healing process.

Essential oils are one of my favorite integrative modalities for histamine overload because they can influence histamine release, address the underlying triggers of an imbalanced immune response, and offer various wellness benefits to enhance our health simultaneously.

In the previous post, I reviewed sixteen oils, from A to L, that are antihistaminic and anti-inflammatory.

Now, in the conclusion of this series, I will complete our collection of histamine and immune balancing oils from M to Z. (Though the last oil ends with “y”.)

During this video blog, I will provide:

• a quick summary of the properties of essential oils that help to mitigate high levels of histamine and balance our overall mind-body wellness
• a review of the four different types of allergic responses that these various oils are most effective for
• a list of the final 16 essential oils (from M to Z) that can lower histamine and are anti-inflammatory

As always, all the resources, references, and links to studies can be found in this accompanying post and/or in the resource section.

So, let’s get started.

 

Why Essential Oils Aid Histamine Balance

In my second vlog in this sequence of posts, I discussed more about how essential oils can harmonize our health and can indirectly impact histamine levels. This is due to their multifaceted properties which include being:

• Anti-inflammatory
• Hormone and neurotransmitters modulators
• Mood supportive
• Anti-microbial
• Digestive aids that enhance assimilation, elimination, gastrointestinal barrier function, and support a healthy microbiome
• Antioxidants (cellular protectors)
• Stress relieving
• Supportive of detoxification of harmful compounds
• Vagus nerve modulators

Due to all these multiple effects, essential oils address many of the underlying external triggers and emotional stressors that fuel excess histamine levels.

Essential oils can also directly impact histamine levels.

In my previous post, I provided you with 16 oils that have direct antihistaminic and anti-inflammatory properties.

Now, let’s look at the next installment of 16 essential oils that can help achieve histamine balance and enhance resiliency. I’ll also review which types of immune reactions they address.

 

The Next Mega-List of Essential Oils That Can Aid Histamine Balance and Allergic Responses (From M to Z)

In my source article from the Creator’s Apothecary, the authors not only described the 32 essential oils that could impact immune modulation, they also highlighted the four types of allergic reactions specific ones could affect. To review, these categories consist of:

• TYPE I, hypersensitivity reaction, or anaphylactic reactions
• TYPE II or cytotoxic reactions (antibodies stimulate the complement pathway causing damage to cellular structures)
• TYPE III or immunocomplex reactions (IgM and IgG antibodies react with an allergen to form immunocomplexes, antigen-antibody complexes)
• TYPE IV or cell-mediated reactions (a delayed type of hypersensitivity linked to delayed skin responses and some autoimmune diseases)

Now, the list…

1. Manuka – Leptospermum scoparium – known as “New Zealand tea tree oil,” this oil can reduce the production of histamine, relax the nervous system, and lower systemic inflammation. It is also antimicrobial and antifungal, helping our bodies to get rid of pathogens that can lead to heightened immune activation.
2. Melissa (Lemon Balm) – Melissa officinalis – is an oil that has antihistaminic action and can help with allergies, eczema, and headaches.
3. Niaouli – Melaleuca quinquenervia  – is an oil that is anti-inflammatory, antiallergic, antihistaminic, and can be helpful for TYPE I allergy responses. Therefore, niaouli may relieve symptoms of rhinitis (nasal inflammation), atopic dermatitis (eczema), asthma, prostatitis (prostate inflammation), inflammatory digestive conditions, and cystitis (inflammation of the bladder).
4. Nutmeg – Myristica fragrans – is an anti-inflammatory, antihistaminic, and immune regulating oil. It is likely helpful for soothing allergies and autoimmune disorders, including Crohn’s disease.
5. Peppermint – Mentha piperita – is an oil that has antispasmodic, anti-inflammatory, and respiratory-supporting properties. Its main constituent, menthol, may assist with alleviating sore throats, colds and flu symptoms, respiratory disorders, and sinusitis. Pre-clinical trials have also found peppermint oil to be antispasmodic (reducing spasms), so it can be used to soothe tightened respiratory muscles. Additionally, peppermint oil may act as an expectorant, helping to ease congestion.
6. Ravensara – Cinnamonum camphora – is an oil known to reduce allergic reactions, enhance resilience, act as an expectorant, decrease inflammation, and strengthen the lungs and respiratory tract. It contains antimicrobial and antifungal compounds, such as limonene and methyl eugenol, which also support the immune system. Ravensara also inhibits the growth of fungus and mold and can kill mold spores.
7. Roman Chamomile – Chamaemelum nobile/Anthemis nobilis – is a natural antihistaminic, anti-allergenic, and anti-inflammatory oil. It is supportive for immediate allergies, including dermatitis, atopic asthma, urticaria (hives), and rhinitis. One study found topical application of Roman chamomile oil could balance and prevent elevated histamine responses. Furthermore, inhalation of Roman chamomile essential oil has a calming effect on the respiratory system, helping to relieve sneezing, blocked sinuses, or excess phlegm.
8. Rosemary – Rosmarinus officinalis ct. Camphor – is an oil that has histamine lowering/mast cell stabilizing properties. It can alleviate allergic responses, relieve stress, and modulate the immune system.
9. Sandalwood – Santalum album – is an oil that has antiallergic and antihistaminic properties.  Sandalwood decreases antibody reactions in the body and inhibits allergic responses. This oil was part of a researched blend that helped to relieve symptoms of allergic rhinitis and enhance quality of life in trial participants.
10. Spikenard – Nardostachys jatamansi – is an oil with anti-inflammatory and antihistamine actions that may be helpful for skin reactions.
11. Spruce –Tsuga Canadensis – is an oil with various compounds that can aid respiratory issues. It is high in camphene, a monoterpene that is a mucolytic and an antioxidant. Additionally, spruce contains a-pinene and bornyl acetate. These constituents are anti-inflammatory, antihistaminic, and analgesic (pain relieving). Finally, the high content of esters in spruce oil contributes to its balancing and antispasmodic properties.
12. Tarragon – Artemisia dracunculus – is an oil that is antiallergic and antihistaminic. It can help with TYPE I allergies, including allergic rhinitis, sinusitis, asthma, dermatitis, gastrointestinal issues, and other inflammatory disorders.
13. Tea Tree – Melaleuca alternifolia – is an antihistaminic and anti-allergic oil. It aids immediate allergic responses, including dermatitis, atopic asthma, urticaria, rhinitis, and more. Tea tree oil has multiple properties such as being antifungal, anti-inflammatory, antimicrobial, and immune modulating. Clinical trials have demonstrated its effectiveness for a variety of skin conditions and to reduce swelling.
14. Thyme – Thymus vulgaris/ Thymus zygis –is another essential oil that has allergy-fighting properties. It can inhibit inflammatory responses and ward off fungal and bacterial infections. Thyme oil also possesses antispasmodic, antimicrobial, antifungal, and antiviral properties.
15. Vetiver – Vetivera zizanioides –is a root oil that helps to ground the body, thus assisting with balancing the immune system. It also possesses antioxidant and anti-inflammatory properties and may aid in circulatory and nervous system disorders.
16. Yarrow – Achillea millefolium – is an oil that is antiallergic, antihistaminic, and tissue-regenerative (mucosal and dermal). It may aid in the relief of atopic eczema/dermatitis, shingles, sinusitis, ear infections, cystitis, and intestinal hyperpermeability.

 

Summary of Essential Oils (From M to Z) for Assisting with Histamine Balance and Immune Resiliency

Histamine serves as a vital chemical messenger involved in numerous physiological processes, including the immune response. However, elevated histamine levels may lead to histamine intolerance and contribute to hypersensitivity reactions, including Mast Cell Activation Syndrome (MCAS).

Essential oils can play a role in modulating histamine levels by supporting immune health and resilience. Several essential oils possess antihistaminic, anti-inflammatory, and calming properties that may help to mitigate symptoms related to allergic reactions and histamine-related disorders.

This post presented the final 16 essential oils (from M to Z ) known for their ability to aid histamine balance.

I’d love to hear about your experience with any of these oils for taming high histamine levels. Please comment below.

Thank you for your interest in learning about the application of essential oils for achieving better mind-body-spirit balance.

Sending many blessings.

 

Interested in Learning More About Essential Oils?

• Calm your nervous system and tone your vagus nerve with the Parasympathetic Blend.
• Find relief with Histamine Balance.™ (special savings link)
• Opt-in for my free weekly newsletter.
• Sign-up for my no-cost, exclusive, space-limited Mind-Body-Heart-Spirit Passion (MBHS) webinar.
• Grab free resources and more education on essential oils and mind-body wellness here.
• For Health Care Providers: Earn CEU’s From My Course on the Clinical Applications of Essential Oils.
• Learn about my community membership program.
• Skim through my branded essential oils website.
• Join my Essential Oils DIY Recipe Group (Facebook)
• Take the Wyld Notes quiz to find your personalized, all-natural, non-toxic signature scent here. (Click here for your 10% coupon code.)

 

Resources:

• When Histamine Goes Haywire: Sixteen Essential Oils (from A to L) for Supporting the Balanced Histamine Levels, Taming Inflammation, and Aiding a Healthy Immune Response (My video blog with references)
• Histamine in Health and Disease. (Clin Allergy Immunol. 2002)
• Too Much Histamine? How to Naturally Boost Your Diamine Oxidase (DAO) Levels (Dr. Jill Carnahan, 2023)
• Impact of Mold on Mast Cell-Cytokine Immune Response (J Biol Regul Homeost Agents. 2018)
• Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern? (Int J Mol Sci, November 2021)
• Characterization of Mast Cell Activation Syndrome (Am J Med Sci. 2017)
• Histamine and Histamine Intolerance (The American Journal of Clinical Nutrition, May 2007)
• Histamine Intolerance: Symptoms, Diagnosis, and Beyond (Nutrients, 2024)
• Mold, Histamine Intolerance, and Mast Cell Activation Syndrome: Everything You Need to Know. (Becky Campell, MD)
• Mast Cell Activation Syndrome: Here’s What You Need to Know When Histamine Goes Haywire (Dr. Jill Carnahan, 2016)
• Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells (Front Pharmacol, April 2022)
• The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19 (Nutrients. 2021)
• Mast Cell Activation Syndrome (Clin Rev Allergy Immunol, June 2018)
• Mast Cell Activation and Histamine Intolerance (Jodi Cohen, VBO)
• Essential Oils for Seasonal Allergies (Jodi Cohen, VBO)
• Essential Oils Considered Antihistamine For Allergic Reactions (Creators Apothecary, 2022) (cross referenced)
• Mast Cells Explained: Biohacking Inflammation, Allergies, and Brain Fog (The Human Upgrade Podcast, September 2025)
• Understanding Histamine Intolerance and MCAS with Michelle Shapiro
  (Conversations for Health, September 2025)
• How Essential Oils Directly Aid Detoxification and Cleansing and Protect Us from Harmful Toxins (My video article with references)
• Limbic Retraining: 10 Strategies to Improve Limbic Function (Dr. Jockers Website)
• My Three Favorite Essential Oils for Supporting the Vagus Nerve (+2 Honorable Mentions) (My video article with references)
• The Five Mind-Body and Mood Benefits of Essential Oils That Support Healthy Detoxification and Enhance Our Mental and Physical Health (My video with references)
• Inhibitory Effects of Geranium Essential Oil and Its Major Component, Citronellol, on Degranulation and Cytokine Production by Mast Cells. (Bioscience, Biotechnology, and Biochemistry, June 2016 )
• Lavender Oil Inhibits Immediate-type Allergic Reaction in Mice and Rats. (Journal of Pharmacy and Pharmacology, February 1999)
• Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial. (Evidence Based Complementary and Alternative Medicine, 2016)
• The Anti-inflammatory Activity of L-menthol Compared to Mint Oil in Human Monocytes in Vitro: A Novel Perspective for its Therapeutic Use in Inflammatory Diseases. (European Journal of Medical Research, December 1998.)
• Antispasmodic Effect of Mentha Piperita Essential Oil on Trachea Smooth Muscle of Rats. (Journal of Ethnopharmacology, 2010).
• Histamine, Neuroinflammation and Neurodevelopment: A Review (Frontiers in Neuroscience, July 2022)
• Intestinal Permeability, Histamine, and Leaky Gut Functional Lab Markers (Dr. Jockers Website)
• 1,8-Cineole (Eucalyptol): A Versatile Phytochemical with Therapeutic Applications Across Multiple Diseases (Biomedicine & Pharmacotherapy. November 2023.)